Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …

Mitochondria play a central role in the pathophysiological processes of acute ischemic
stroke. Disruption of the cerebral blood flow during acute ischemic stroke interrupts oxygen …

Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease
(AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a …

Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of
Alzheimer's disease (AD) patients. Recent studies suggest that mitochondrial dysfunction …

Mitochondria are the main cellular energy powerhouses and supply most of the energy in
the form of ATP to fuel essential neuronal functions through oxidative phosphorylation …

Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in
synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD) …

Retinal ganglion cells (RGCs) are the only afferent neurons that can transmit visual
information to the brain. The death of RGCs occurs in the early stages of glaucoma, diabetic …

Maintenance of neuronal homeostasis is a challenging task, due to unique cellular
organization and bioenergetic demands of post-mitotic neurons. It is increasingly …

Disarrangement in functions and quality control of mitochondria at synapses are early
events in Alzheimer's disease (AD) pathobiology. We reported that a 20–22 kDa NH2-tau …

Stroke is a devastating disease with high mortality and disability rates. Previous research
has established that mitochondria, as major regulators, are both influenced by stroke, and …