Cannabis-associated psychosis: Neural substrate and clinical impact

RM Murray, A Englund, A Abi-Dargham, DA Lewis… - …, 2017 - Elsevier
Prospective epidemiological studies have consistently demonstrated that cannabis use is
associated with an increased subsequent risk of both psychotic symptoms and …

Endocannabinoid system components as potential biomarkers in psychiatry

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2020 - frontiersin.org
The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

Consensus paper of the WFSBP task force on cannabis, cannabinoids and psychosis

DC D'Souza, M DiForti, S Ganesh… - The World Journal of …, 2022 - Taylor & Francis
Objectives The liberalisation of cannabis laws, the increasing availability and potency of
cannabis has renewed concern about the risk of psychosis with cannabis. Methods The …

Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice

A Ortega-Alvaro, A Aracil-Fernández… - …, 2011 - nature.com
The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Endocannabinoid system in psychotic and mood disorders, a review of human studies

R Garani, JJ Watts, R Mizrahi - Progress in Neuro-Psychopharmacology …, 2021 - Elsevier
Despite widespread evidence of endocannabinoid system involvement in the
pathophysiology of psychiatric disorders, our understanding remains rudimentary. Here we …

Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C] OMAR

DF Wong, H Kuwabara, AG Horti, V Raymont, J Brasic… - Neuroimage, 2010 - Elsevier
Several studies have examined the link between the cannabinoid CB1 receptor and several
neuropsychiatric illnesses, including schizophrenia. As such, there is a need for in vivo …

Adenosine receptor control of cognition in normal and disease

JF Chen - International review of neurobiology, 2014 - Elsevier
Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

Cannabidiol as a potential treatment for psychosis

CD Schubart, IEC Sommer, P Fusar-Poli… - European …, 2014 - Elsevier
Although cannabis use is associated with an increased risk of developing psychosis, the
cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review …

Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain

SS Kaalund, EN Newburn, T Ye, R Tao, C Li… - Molecular …, 2014 - nature.com
Abstract Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of
schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ …

The possible role of the Akt signaling pathway in schizophrenia

W Zheng, H Wang, Z Zeng, J Lin, PJ Little… - Brain research, 2012 - Elsevier
Serine/threonine protein kinase v-akt murine thymoma viral oncogene homolog (Akt) is one
of the survival kinases with multiple biological functions in the brain and throughout the …