Gene therapy: Comprehensive overview and therapeutic applications

N Sayed, P Allawadhi, A Khurana, V Singh, U Navik… - Life sciences, 2022 - Elsevier
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

Next‐generation vaccines: nanoparticle‐mediated DNA and mRNA delivery

W Ho, M Gao, F Li, Z Li, XQ Zhang… - Advanced healthcare …, 2021 - Wiley Online Library
Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …

[HTML][HTML] Emerging applications of nanotechnology in healthcare systems: Grand challenges and perspectives

S Anjum, S Ishaque, H Fatima, W Farooq, C Hano… - Pharmaceuticals, 2021 - mdpi.com
Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …

[HTML][HTML] Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine

CS Lee, ES Bishop, R Zhang, X Yu, EM Farina, S Yan… - Genes & diseases, 2017 - Elsevier
With rapid advances in understanding molecular pathogenesis of human diseases in the era
of genome sciences and systems biology, it is anticipated that increasing numbers of …

[HTML][HTML] Gene therapy: advances, challenges and perspectives

GAR Gonçalves, RMA Paiva - Einstein (Sao Paulo), 2017 - SciELO Brasil
The ability to make site-specific modifications to the human genome has been an objective
in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene …

[HTML][HTML] Viral and nonviral delivery systems for gene delivery

N Nayerossadat, T Maedeh, PA Ali - Advanced biomedical …, 2012 - journals.lww.com
Gene therapy is the process of introducing foreign genomic materials into host cells to elicit
a therapeutic benefit. Although initially the main focus of gene therapy was on special …

Gene therapy and DNA delivery systems

D Ibraheem, A Elaissari, H Fessi - International journal of pharmaceutics, 2014 - Elsevier
Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

[HTML][HTML] Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy

F Zhang, L Cong, RAN Fei - US Patent 10,577,630, 2020 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Large-pore ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery.

M Wu, Q Meng, Y Chen, Y Du, L Zhang… - … (Deerfield Beach, Fla.), 2014 - europepmc.org
A novel micelle/precursor co-templating assembly strategy is successfully developed to
synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs) …