A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …

The eye as a biomarker for Alzheimer's disease

JKH Lim, QX Li, Z He, AJ Vingrys, VHY Wong… - Frontiers in …, 2016 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia
and eventual death. It is the leading cause of dementia and the number of cases are …

Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

S Chang, AK Bowden - Journal of biomedical optics, 2019 - spiedigitallibrary.org
The optical attenuation coefficient (AC), an important tissue parameter that measures how
quickly incident light is attenuated when passing through a medium, has been shown to …

Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis

P Manogaran, M Samardzija, AN Schad… - Acta neuropathologica …, 2019 - Springer
The exact mechanisms and temporal sequence of neurodegeneration in multiple sclerosis
are still unresolved. The visual pathway including its unmyelinated retinal axons, can serve …

[HTML][HTML] The effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer in spectral domain optical coherence tomography images

J Van Der Schoot, KA Vermeer… - … & visual science, 2012 - arvojournals.org
Purpose.: To demonstrate the effect of glaucoma on the optical attenuation coefficient of the
retinal nerve fiber layer (RNFL) in Spectral Domain Optical Coherence Tomography (SD …

Details of glaucomatous damage are better seen on OCT en face images than on OCT retinal nerve fiber layer thickness maps

DC Hood, B Fortune, MA Mavrommatis… - … & visual science, 2015 - iovs.arvojournals.org
Purpose: High-resolution images of glaucomatous damage to the retinal nerve fiber layer
(RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) …

RPE-normalized RNFL attenuation coefficient maps derived from volumetric OCT imaging for glaucoma assessment

KA Vermeer, J van der Schoot… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: We present spatial retinal nerve fiber layer (RNFL) attenuation coefficient maps for
healthy and glaucomatous eyes based on optical coherence tomography (OCT) …

Onset and progression of peripapillary retinal nerve fiber layer (RNFL) retardance changes occur earlier than RNFL thickness changes in experimental glaucoma

B Fortune, CF Burgoyne, G Cull… - … & visual science, 2013 - iovs.arvojournals.org
Purpose.: Longitudinal measurements of peripapillary RNFL thickness and retardance were
compared in terms of time to reach onset of damage and time to reach a specific progression …

Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma

B Fortune, CF Burgoyne, GA Cull… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: To compare peripapillary retinal nerve fiber layer thickness (RNFLT), RNFL
retardance, and retinal function at the onset of optic nerve head (ONH) surface topography …

[HTML][HTML] Reflectance decreases before thickness changes in the retinal nerve fiber layer in glaucomatous retinas

XR Huang, Y Zhou, W Kong… - … ophthalmology & visual …, 2011 - jov.arvojournals.org
Purpose.: Glaucoma damages the retinal never fiber layer (RNFL). RNFL thickness,
measured with optical coherence tomography (OCT), is often used in clinical assessment of …