[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and-unwinding activities
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …
Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities
SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …
[HTML][HTML] Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Anti-viral and immunomodulatory properties of propolis: Chemical diversity, pharmacological properties, preclinical and clinical applications, and in silico …
Propolis, a resin produced by honeybees, has long been used as a dietary supplement and
folk remedy, and more recent preclinical investigations have demonstrated a large spectrum …
folk remedy, and more recent preclinical investigations have demonstrated a large spectrum …
Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion
A Hossain, S Akter, AA Rashid, S Khair… - Microbial …, 2022 - Elsevier
SARS-CoV-2 is the causative agent behind the ongoing COVID-19 pandemic. This virus is a
cumulative outcome of mutations, leading to frequent emergence of new variants and their …
cumulative outcome of mutations, leading to frequent emergence of new variants and their …
[HTML][HTML] Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …
expression. Structural analyses revealed the basis for coupling of the essential nsp13 …
[HTML][HTML] SARS-CoV-2 non-structural proteins and their roles in host immune evasion
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …
continues to threaten public health. The etiological agent of this devastating pandemic …
[HTML][HTML] SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
SY Fung, KL Siu, H Lin, CP Chan, ML Yeung, DY Jin - Cell & bioscience, 2022 - Springer
Background SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release
of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of …
of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of …