Understanding the structural dynamics of TCR-pMHC interactions
Dynamics plays an important but underappreciated role in the interaction between the T cell
receptor (TCR) and peptide-bound major histocompatibility complex (pMHC) …
receptor (TCR) and peptide-bound major histocompatibility complex (pMHC) …
Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor
A Kumar, F Delogu - Scientific reports, 2017 - nature.com
The present work focuses on the dynamical aspects of cross-reactivity between myelin
based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy. 1B11 T …
based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy. 1B11 T …
Large scale characterization of the LC13 TCR and HLA-B8 structural landscape in reaction to 172 altered peptide ligands: a molecular dynamics simulation study
The interplay between T cell receptors (TCRs) and peptides bound by major
histocompatibility complexes (MHCs) is one of the most important interactions in the …
histocompatibility complexes (MHCs) is one of the most important interactions in the …
Dynamical insights into the differential characteristics of Mycobacterium avium subsp. paratuberculosis peptide binding to HLA-DRB1 proteins associated with multiple …
Mycobacterium avium subsp. paratuberculosis (MAP) infections have been recently linked to
multiple sclerosis in Sardinian population, with an amino acid sequence 301–309 of …
multiple sclerosis in Sardinian population, with an amino acid sequence 301–309 of …
Quantitative analysis of the association angle between T-cell receptor Vα/Vβ domains reveals important features for epitope recognition
T Hoffmann, AM Krackhardt, I Antes - PLoS computational biology, 2015 - journals.plos.org
T-cell receptors (TCR) play an important role in the adaptive immune system as they
recognize pathogen-or cancer-based epitopes and thus initiate the cell-mediated immune …
recognize pathogen-or cancer-based epitopes and thus initiate the cell-mediated immune …
Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35–55 epitope implicated in multiple sclerosis
MP Yannakakis, H Tzoupis, E Michailidou… - Journal of Molecular …, 2016 - Elsevier
Multiple Sclerosis (MS) is a common autoimmune disease whereby myelin is destroyed by
the immune system. The disease is triggered by the stimulation of encephalitogenic T-cells …
the immune system. The disease is triggered by the stimulation of encephalitogenic T-cells …
How peptide/MHC presence affects the dynamics of the LC13 T-cell receptor
JL Dominguez, B Knapp - Scientific Reports, 2019 - nature.com
The interaction between T-cell receptors (TCRs) of T-cells and potentially immunogenic
peptides presented by MHCs of antigen presenting cells is one of the most important …
peptides presented by MHCs of antigen presenting cells is one of the most important …
Intramolecular domain movements of free and bound pMHC and TCR proteins: a molecular dynamics simulation study
R Karch, C Stocsits, N Ilieva, W Schreiner - Cells, 2019 - mdpi.com
The interaction of antigenic peptides (p) and major histocompatibility complexes (pMHC)
with T-cell receptors (TCR) is one of the most important steps during the immune response …
with T-cell receptors (TCR) is one of the most important steps during the immune response …
Energetic and flexibility properties captured by long molecular dynamics simulations of a membrane-embedded pMHCII–TCR complex
M Bello, J Correa-Basurto - Molecular BioSystems, 2016 - pubs.rsc.org
Although crystallographic data have provided important molecular insight into the
interactions in the pMHC–TCR complex, the inherent features of this structural approach …
interactions in the pMHC–TCR complex, the inherent features of this structural approach …
Early relaxation dynamics in the LC 13 T cell receptor in reaction to 172 altered peptide ligands: a molecular dynamics simulation study
B Knapp, G Dorffner, W Schreiner - PloS one, 2013 - journals.plos.org
The interaction between the T cell receptor and the major histocompatibility complex is one
of the most important events in adaptive immunology. Although several different models for …
of the most important events in adaptive immunology. Although several different models for …