Toward neurosubtypes in autism

SJ Hong, JT Vogelstein, A Gozzi, BC Bernhardt… - Biological …, 2020 - Elsevier
There is a consensus that substantial heterogeneity underlies the neurobiology of autism
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …

Large-scale functional connectivity networks in the rodent brain

A Gozzi, AJ Schwarz - Neuroimage, 2016 - Elsevier
Abstract Resting-state functional Magnetic Resonance Imaging (rsfMRI) of the human brain
has revealed multiple large-scale neural networks within a hierarchical and complex …

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

PN Alves, C Foulon, V Karolis, D Bzdok… - Communications …, 2019 - nature.com
The brain is constituted of multiple networks of functionally correlated brain areas, out of
which the default-mode network (DMN) is the largest. Most existing research into the DMN …

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

M Pagani, N Barsotti, A Bertero, S Trakoshis… - Nature …, 2021 - nature.com
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

Y Zhan, RC Paolicelli, F Sforazzini, L Weinhard… - Nature …, 2014 - nature.com
Microglia are phagocytic cells that infiltrate the brain during development and have a role in
the elimination of synapses during brain maturation. Changes in microglial morphology and …

Unique spatiotemporal fMRI dynamics in the awake mouse brain

D Gutierrez-Barragan, NA Singh, FG Alvino, L Coletta… - Current biology, 2022 - cell.com
Human imaging studies have shown that spontaneous brain activity exhibits stereotypic
spatiotemporal reorganization in awake, conscious conditions with respect to minimally …

Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex

F Rocchi, C Canella, S Noei… - Nature …, 2022 - nature.com
While shaped and constrained by axonal connections, fMRI-based functional connectivity
reorganizes in response to varying interareal input or pathological perturbations. However …

Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns

J Grandjean, A Schroeter, I Batata, M Rudin - Neuroimage, 2014 - Elsevier
Resting state-fMRI (rs-fMRI) in mice allows studying mechanisms underlying functional
connectivity (FC) as well as alterations of FC occurring in murine models of neurological …

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

J Grandjean, C Canella, C Anckaerts, G Ayrancı… - Neuroimage, 2020 - Elsevier
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer
the possibility to non-invasively probe whole-brain network dynamics and to investigate the …

Infraslow state fluctuations govern spontaneous fMRI network dynamics

D Gutierrez-Barragan, MA Basson, S Panzeri, A Gozzi - Current Biology, 2019 - cell.com
Spontaneous brain activity as assessed with resting-state fMRI exhibits rich spatiotemporal
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …