Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

The trade-off between survival and reproduction is the bedrock of the evolutionary theory of
ageing. The reproductive system regulates ageing of the soma, and removal of germ cells …

Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in
lifespan extension are not clear. Here, by using the nematode C. elegans, we identified that …

Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles,
but the contribution of lipid distribution to life-span extension is not fully understood. Here we …

There is growing interest in pharmacological interventions directly targeting the aging
process. Pharmacological interventions against aging should be efficacious when started in …