Inflammation is an unstable state. It either resolves or persists. Why inflammation persists
and the factors that define tissue tropism remain obscure. Increasing evidence suggests that …

Adverse Local Tissue Reactions (ALTRs) are one of the main causes of hip implant failures.
Although the metal release from the implants is considered as a main etiology, the …

Pathological assessment of periprosthetic tissues is important, not only for diagnosis, but
also for understanding the pathobiology of implant failure. The host response to wear …

Tissue engineering (TE) for tissue and organ regeneration or replacement is generally
performed with scaffold implants, which provide structural and molecular support to in vitro …

Immunoengineering applies quantitative and materials-based approaches for the
investigation of the immune system and for the development of therapeutic solutions for …

Degradation of the implant surface and particle release/formation as an inflammation
catalyst mechanism is an emerging concept in dental medicine that may help explain the …

Increased failure rates due to metallic wear particle-associated adverse local tissue
reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty …

Classically, particle-induced periprosthetic osteolysis at the implant–bone interface has
explained the aseptic loosening of joint replacement. This response is preceded by …

Background Adverse local tissue reaction (ALTR), characterized by a heterogeneous
cellular inflammatory infiltrate and the presence of corrosion products in the periprosthetic …

Magnesium-based implants (Mg) became an attractive candidate in orthopedic surgery due
to their valuable properties, such as osteoconductivity, biodegradability, elasticity and …