Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

A growing body of evidence supports the notion that angiotensin II (Ang II), the central
product of the renin-angiotensin system, may play a central role not only in the etiology of …

Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

Results The a and p cardiac MHC genes are only 4.5 kb apart (Saez et al., 1987; Matsuoka
et al., 1989). Each gene consists of 40 exons and encompasses approximately 30 kb of …

Background During the development of heart failure (HF), the chief myocardial energy
substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates …

Hyperglycemia is associated with altered myocardial substrate use, a condition that has
been hypothesized to contribute to impaired cardiac performance. The goals of this study …

Angiotensin II (Ang II), a potent hypertrophic stimulus, causes significant increases in TGFb1
gene expression. However, it is not known whether there is a causal relationship between …

Exercise training fosters the health and performance of the cardiovascular system, and
represents nowadays a powerful tool for cardiovascular therapy. Exercise exerts its …

Sex has a profound impact on myocardial remodeling, which is defined as the molecular
and cellular events after an injury to the myocardium (ie, necrosis, pressure overload …