Abstract The trans-2, 3-disubstituted piperidine, quinazolinone-containing natural product
febrifugine (also known as dichroine B) and its synthetic analogue, halofuginone, possess …

Abstract The quinazolinone-containing 2, 3-disubstituted piperidines febrifugine and
isofebrifugine have been the subject of significant research efforts since their occurrence in …

The asymmetric dihydroxylation of amino-functionalized vinyl sulfone 19 has been used for
the 3-step preparation of 3-hydroxylpiperidine 24 in 86% enantiomeric excess. This …

An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to
result in 3, 5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were …

The asymmetric BF3· Et2O catalyzed nucleophilic reactions of 3-silyloxypiperidine N, O-
acetal 10 with silyl enol ethers derived from ketones are described.(+)-Febrifugine 1, an …

A diastereoselective intramolecular aza-Michael reaction between N-Cbz carbamates and
enones was studied. The investigation revealed that Brønsted acids with different strengths …

A simple and convenient method for the synthesis of fused dihydrofuran derivatives using
NaBH4-mediated reductive cyclization and fused furan derivatives by K2CO3-mediated …

A new synthesis of both enantiomers of naturally occurring febrifugine (1) and its analogue
halofuginone (3) are reported. This robust route relies on an enzymatic kinetic resolution …

Two complementary strategies for the synthesis of febrifugine are detailed based on
previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton …

Synthetically versatile conjugate addition of a range of carbon, nitrogen, oxygen, sulfur and
selenium nucleophiles to the highly functionalised 2-thio-3-chloroacrylamides is described …