Molecular regulation of fungal secondary metabolism

W Yu, R Pei, J Zhou, B Zeng, Y Tu, B He - World Journal of Microbiology …, 2023 - Springer
Many bioactive secondary metabolites synthesized by fungi have important applications in
many fields, such as agriculture, food, medical and others. The biosynthesis of secondary …

Novel treatment approach for aspergilloses by targeting germination

K Verburg, J van Neer, M Duca, H de Cock - Journal of Fungi, 2022 - mdpi.com
Germination of conidia is an essential process within the Aspergillus life cycle and plays a
major role during the infection of hosts. Conidia are able to avoid detection by the majority of …

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple …

C Sasse, E Bastakis, F Bakti, AM Höfer, I Zangl… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Z inc c luster transcription f actors (Zcfs) encoding zcf genes are exclusive for
fungi and required for multiple cellular processes including metabolism and development …

Integration analysis of transcriptomics and proteomics reveals the inhibitory effect of carvacrol on Alternaria alternata by interfering with carbohydrate metabolism

L Zhao, J Wang, H Zhang, Y Zhou, C Wang… - Postharvest Biology and …, 2024 - Elsevier
The cell wall of pathogenic fungi is critical for maintaining cell integrity and promoting host
infection. Our previous study found that carvacrol (CVR) can inhibit the growth of Alternaria …

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

R Silva-Gomes, I Caldeira, R Fernandes… - Journal of Leukocyte …, 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …

Effect of process mode, nitrogen source and temperature on L-malic acid production with Aspergillus oryzae DSM 1863 using acetate as carbon source

A Kövilein, L Zadravec, S Hohmann… - … in Bioengineering and …, 2022 - frontiersin.org
Malic acid, mainly used as acidulant and taste enhancer in the food industry, is currently
produced from fossil resources. In this study, microbial L-malate production with the …

Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …

Targeting immunometabolism in host-directed therapies to fungal disease

SM Gonçalves, AV Ferreira, C Cunha… - Clinical and …, 2022 - academic.oup.com
Fungal infections affect over a billion people and are responsible for more than 1.5 million
deaths each year. Despite progress in diagnostic and therapeutic approaches, the …

Implications of carbon catabolite repression for Aspergillus‐based cell factories: A review

ZD Wang, BT Wang, L Jin, HH Ruan… - Biotechnology …, 2024 - Wiley Online Library
Carbon catabolite repression (CCR) is a global regulatory mechanism that allows organisms
to preferentially utilize a preferred carbon source (usually glucose) by suppressing the …

Structural characterization of the reaction and substrate specificity mechanisms of pathogenic fungal acetyl-CoA synthetases

AJ Jezewski, KM Alden, TE Esan… - ACS chemical …, 2021 - ACS Publications
Acetyl CoA synthetases (ACSs) are A cyl-CoA/N RPS/L uciferase (ANL) superfamily
enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central …