Molecular regulation of fungal secondary metabolism
W Yu, R Pei, J Zhou, B Zeng, Y Tu, B He - World Journal of Microbiology …, 2023 - Springer
Many bioactive secondary metabolites synthesized by fungi have important applications in
many fields, such as agriculture, food, medical and others. The biosynthesis of secondary …
many fields, such as agriculture, food, medical and others. The biosynthesis of secondary …
Novel treatment approach for aspergilloses by targeting germination
K Verburg, J van Neer, M Duca, H de Cock - Journal of Fungi, 2022 - mdpi.com
Germination of conidia is an essential process within the Aspergillus life cycle and plays a
major role during the infection of hosts. Conidia are able to avoid detection by the majority of …
major role during the infection of hosts. Conidia are able to avoid detection by the majority of …
Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple …
C Sasse, E Bastakis, F Bakti, AM Höfer, I Zangl… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Z inc c luster transcription f actors (Zcfs) encoding zcf genes are exclusive for
fungi and required for multiple cellular processes including metabolism and development …
fungi and required for multiple cellular processes including metabolism and development …
Integration analysis of transcriptomics and proteomics reveals the inhibitory effect of carvacrol on Alternaria alternata by interfering with carbohydrate metabolism
L Zhao, J Wang, H Zhang, Y Zhou, C Wang… - Postharvest Biology and …, 2024 - Elsevier
The cell wall of pathogenic fungi is critical for maintaining cell integrity and promoting host
infection. Our previous study found that carvacrol (CVR) can inhibit the growth of Alternaria …
infection. Our previous study found that carvacrol (CVR) can inhibit the growth of Alternaria …
Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities
R Silva-Gomes, I Caldeira, R Fernandes… - Journal of Leukocyte …, 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
Effect of process mode, nitrogen source and temperature on L-malic acid production with Aspergillus oryzae DSM 1863 using acetate as carbon source
A Kövilein, L Zadravec, S Hohmann… - … in Bioengineering and …, 2022 - frontiersin.org
Malic acid, mainly used as acidulant and taste enhancer in the food industry, is currently
produced from fossil resources. In this study, microbial L-malate production with the …
produced from fossil resources. In this study, microbial L-malate production with the …
Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems
H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …
Targeting immunometabolism in host-directed therapies to fungal disease
SM Gonçalves, AV Ferreira, C Cunha… - Clinical and …, 2022 - academic.oup.com
Fungal infections affect over a billion people and are responsible for more than 1.5 million
deaths each year. Despite progress in diagnostic and therapeutic approaches, the …
deaths each year. Despite progress in diagnostic and therapeutic approaches, the …
Implications of carbon catabolite repression for Aspergillus‐based cell factories: A review
ZD Wang, BT Wang, L Jin, HH Ruan… - Biotechnology …, 2024 - Wiley Online Library
Carbon catabolite repression (CCR) is a global regulatory mechanism that allows organisms
to preferentially utilize a preferred carbon source (usually glucose) by suppressing the …
to preferentially utilize a preferred carbon source (usually glucose) by suppressing the …
Structural characterization of the reaction and substrate specificity mechanisms of pathogenic fungal acetyl-CoA synthetases
Acetyl CoA synthetases (ACSs) are A cyl-CoA/N RPS/L uciferase (ANL) superfamily
enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central …
enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central …