Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Mycobacterium tuberculosis Infection-Driven Foamy Macrophages and Their Implications in Tuberculosis Control as Targets for Host-Directed Therapy

D Shim, H Kim, SJ Shin - Frontiers in immunology, 2020 - frontiersin.org
Tuberculosis (TB) is a leading cause of death worldwide following infection with
Mycobacterium tuberculosis (Mtb), with 1.5 million deaths from this disease reported in …

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

M Ouimet, S Koster, E Sakowski, B Ramkhelawon… - Nature …, 2016 - nature.com
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the
lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source …

Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis

T Laval, L Chaumont, C Demangel - Immunological Reviews, 2021 - Wiley Online Library
While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Cholesterol-dependent transcriptome remodeling reveals new insight into the contribution of cholesterol to Mycobacterium tuberculosis pathogenesis

J Pawełczyk, A Brzostek, A Minias, P Płociński… - Scientific reports, 2021 - nature.com
Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the
various nutrients available during its life cycle. However, in the nutritionally stringent …

Underestimated Manipulative Roles of Mycobacterium tuberculosis Cell Envelope Glycolipids During Infection

A Garcia-Vilanova, J Chan, JB Torrelles - Frontiers in immunology, 2019 - frontiersin.org
The Mycobacterium tuberculosis cell envelope has been evolving over time to make the
bacterium transmissible and adaptable to the human host. In this context, the M. tuberculosis …

Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing

RA Rienksma, M Suarez-Diez, HJ Mollenkopf… - BMC genomics, 2015 - Springer
Abstract Background The human pathogen Mycobacterium tuberculosis has the capacity to
escape eradication by professional phagocytes. During infection, M. tuberculosis resists the …

Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy

DPS Chang, XL Guan - Metabolites, 2021 - mdpi.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly
successful intracellular pathogen with the ability to withstand harsh conditions and reside …

Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism

H Kim, SJ Shin - Cellular and Molecular Life Sciences, 2023 - Springer
Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …

Triacylglycerols: Fuelling the Hibernating Mycobacterium tuberculosis

RK Maurya, S Bharti, MY Krishnan - Frontiers in cellular and infection …, 2019 - frontiersin.org
Mycobacterium tuberculosis (Mtb) has the remarkable ability to persist with a modified
metabolic status and phenotypic drug tolerance for long periods in the host without …