Slowing the progression of Alzheimer disease (AD) might be the greatest unmet medical
need of our time. Although one AD therapeutic has received a controversial accelerated …

Background Coronavirus disease 2019 (COVID-19) has been the most important global
issue since December 2019. Although the clinical course of COVID-19 is known to be milder …

Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth
impairments. Individuals with DS are also prone to severe infections and autoimmunity …

Die STIKO empfiehlt die Impfung gegen COVID-19 mit einem der beiden zugelassenen
mRNA-Impfstoffe (Comirnaty von BioNTech/Pfizer, COVID-19-Vaccine von Moderna) oder …

Down syndrome (DS) is typically caused by triplication of chromosome 21. Phenotypically,
DS presents with developmental, neurocognitive, and immune features. Epidemiologically …

Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …

BACKGROUND: Recent advances in medical care have increased life expectancy and
improved the quality of life for people with Down syndrome (DS). These advances are the …

Although more than 90% of children born with congenital heart disease (CHD) survive into
adulthood, patients face significantly higher and premature morbidity and mortality. Heart …

Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …

The risk of severe outcomes following respiratory tract infections is significantly increased in
individuals over 60 years, especially in those with chronic medical conditions, ie …