Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

C Munteanu, MA Turnea, M Rotariu - Antioxidants, 2023 - mdpi.com
Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical
regulator in many biological processes, including oxidative stress and cellular homeostasis …

Novel Multi-antioxidant Approach for ischemic stroke therapy targeting the role of oxidative stress

C Briones-Valdivieso, F Briones, S Orellana-Urzúa… - Biomedicines, 2024 - mdpi.com
Stroke is a major contributor to global mortality and disability. While reperfusion is essential
for preventing neuronal death in the penumbra, it also triggers cerebral ischemia …

[HTML][HTML] Exploring intrinsic disorder in human synucleins and associated proteins

SR Venati, VN Uversky - International Journal of Molecular Sciences, 2024 - mdpi.com
In this work, we explored the intrinsic disorder status of the three members of the synuclein
family of proteins—α-, β-, and γ-synucleins—and showed that although all three human …

Potential regulation of dietary lipophilic antioxidants by mitochondrial contact sites

FJG Muriana - Trends in Food Science & Technology, 2024 - Elsevier
Background Recent evidence has brought the mitochondrial contact sites, in communication
with other organelles, to the centre of interest in cellular metabolism because of their …

Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases

S Oh, XL Mai, J Kim, ACV de Guzman, JY Lee… - … & Molecular Medicine, 2024 - nature.com
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic
NAD+-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked …

Silibinin inhibits PM2. 5-induced liver triglyceride accumulation through enhancing the function of mitochondrial Complexes I and II

D Li, J Zhang, Y Jin, Y Zhu, X Lu, X Huo… - Frontiers in …, 2024 - frontiersin.org
Background The standardized extract of milk thistle seeds, known as silibinin, has been
utilized in herbal medicine for over two centuries, with the aim of safeguarding the liver …

An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH

Y Sun, Y Mao, T Bai, T Ye, Y Lin, F Wang, L Li… - Chemical …, 2024 - pubs.rsc.org
A novel NIR fluorescent probe based on quinoline-conjugated benzo [cd] indol dual-salt for
NADH was developed. This probe swiftly detects and responds sensitively to both …

Flavonoid–Phenolic Acid Hybrids Are Potent Inhibitors of Ferroptosis via Attenuation of Mitochondrial Impairment

M Günther, S Dabare, J Fuchs, S Gunesch, J Hofmann… - Antioxidants, 2023 - mdpi.com
Cinnamic acid, ferulic acid, and the flavonoids quercetin and taxifolin (dihydroquercetin) are
naturally occurring compounds found in plants. They are often referred to as polyphenols …

[HTML][HTML] Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294

YH Lee, BH So, KS Lee, MU Kuk, JH Park, JH Yoon… - Molecules, 2024 - mdpi.com
As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing
cellular damage. Flavonoids derived from natural products are known for their antioxidant …

Comprehensive Management of Stroke: From Mechanisms to Therapeutic Approaches

A Arnalich-Montiel, A Burgos-Santamaría… - International Journal of …, 2024 - mdpi.com
Acute ischemic stroke (AIS) is a challenging disease, which needs urgent comprehensive
management. Endovascular thrombectomy (EVT), alone or combined with iv thrombolysis, is …