Ion channels and transporters as therapeutic agents: from biomolecules to supramolecular medicinal chemistry
G Picci, S Marchesan, C Caltagirone - Biomedicines, 2022 - mdpi.com
Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …
variety of physiological and pathological processes. Traditional therapies include many ion …
[HTML][HTML] Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers
Z Xia, D He, Y Wu, HF Kwok, Z Cao - Pharmacological Research, 2023 - Elsevier
Animal venom is an important evolutionary innovation in nature. As one of the most
representative animal venoms, scorpion venom contains an extremely diverse set of …
representative animal venoms, scorpion venom contains an extremely diverse set of …
Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity
Over-expression of K+ channels has been reported in human cancers and is associated with
the poor prognosis of several malignancies. EAG1, a particular potassium ion channel, is …
the poor prognosis of several malignancies. EAG1, a particular potassium ion channel, is …
Harnessing the potency of scorpion venom-derived proteins: applications in cancer therapy
J El-Qassas, M Abd El-Atti, N El-Badri - Bioresources and Bioprocessing, 2024 - Springer
Despite breakthroughs in the development of cancer diagnosis and therapy, most current
therapeutic approaches lack precise specificity and sensitivity, resulting in damage to …
therapeutic approaches lack precise specificity and sensitivity, resulting in damage to …
Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway
X You, J Qiu, Q Li, Q Zhang, W Sheng, Y Cao, W Fu - BMC cancer, 2024 - Springer
Abstract Background Prostate cancer (PCa) is becoming the most common malignancy in
men worldwide. We investigated the effect of astragaloside IV combined with PESV on the …
men worldwide. We investigated the effect of astragaloside IV combined with PESV on the …
Astragalus–Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy
X You, Y Wu, Q Li, W Sheng, Q Zhou… - Frontiers in …, 2022 - frontiersin.org
Objective: Prostate cancer (PCa) is an epithelial malignancy of the prostate that currently
lacks effective treatment. Traditional Chinese medicine (TCM) can play an anticancer role …
lacks effective treatment. Traditional Chinese medicine (TCM) can play an anticancer role …
Kinetic and Thermodynamic Study of Margatoxin Peptide Interaction with Human Serum Albumin: Studied by Biophysical and Docking Methods
F Ranjbari, A Nosrat, M Zaefizadeh, F Fathi - International Journal of …, 2024 - Springer
The scorpion-derived peptide margatoxin (MgTx) can make it possible to create novel and
targeted medications for treatment of cancer. In this study, for the first time, we report an …
targeted medications for treatment of cancer. In this study, for the first time, we report an …
Anticancer potentiality of Hottentotta saulcyi scorpion curd venom against breast cancer: an in vitro and in vivo study
M Nosouhian, AA Rastegari, K Shahanipour… - Scientific Reports, 2024 - nature.com
Scorpion venom may include pharmacological substances that have the potential to provide
benefits. Multiple scientific investigations have shown that particular scorpion venoms …
benefits. Multiple scientific investigations have shown that particular scorpion venoms …
[HTML][HTML] Therapeutic Potential of Solenopsis invicta Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications
Solenopsis invicta, a South American ant species from the Formicidae family (subfamily
Myrmicinae), has recently established a stable settlement in Europe, raising public health …
Myrmicinae), has recently established a stable settlement in Europe, raising public health …
SPAD-1, a serine proteinase associated disintegrin from Russell's viper venom disrupts adhesion of MCF7 human breast cancer cells
Abstract Serine Proteinase Associated Disintegrin-1 (SPAD-1) is a low molecular mass (26
kDa) positively charged protein purified from Russell's viper venom (RVV) possessing …
kDa) positively charged protein purified from Russell's viper venom (RVV) possessing …