Diverse biological activities of 1, 3, 4-thiadiazole scaffold
T Anthwal, S Paliwal, S Nain - Chemistry, 2022 - mdpi.com
The chemistry of 1, 3, 4-thiadiazole is one of the most interesting scaffolds for synthesizing
new drug molecules due to their numerous pharmacological activities. Several modifications …
new drug molecules due to their numerous pharmacological activities. Several modifications …
Comparative study of the synthetic approaches and biological activities of the bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles over the past decade
The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …
Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation
2-Amino-substituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles were synthesized via
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …
condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes …
Multi-method evaluation of a 2-(1, 3, 4-thiadiazole-2-yl) pyrrolidine corrosion inhibitor for mild steel in HCl: combining gravimetric, electrochemical, and DFT …
A Al-Amiery, WNRW Isahak, WK Al-Azzawi - Scientific Reports, 2023 - nature.com
The corrosion inhibition properties of 2-(1, 3, 4-thiadiazole-2-yl) pyrrolidine (2-TP) on mild
steel in a 1 M HCl solution were investigated using weight loss, potentiodynamic …
steel in a 1 M HCl solution were investigated using weight loss, potentiodynamic …
Synthesis of isatin-tagged thiadiazoles as anti-breast cancer leads: In-vitro and in-silico investigations
J Rasgania, R Gavadia, S Nimesh, L Loveleen… - Journal of Molecular …, 2023 - Elsevier
Despite rapid advances in drug accessibility for diagnosis and treatment, breast cancer
remains a common malignancy among women across the world due to the inadequacy of …
remains a common malignancy among women across the world due to the inadequacy of …
5-(Thiophen-2-yl)-1, 3, 4-thiadiazole derivatives: Synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
SM Gomha, MM Edrees, ZA Muhammad… - Drug Design …, 2018 - Taylor & Francis
Background Nowadays, cancer is an important public health problem in all countries.
Limitations of current chemotherapy for neoplastic diseases such as severe adverse …
Limitations of current chemotherapy for neoplastic diseases such as severe adverse …
Computational study of quinoline-based thiadiazole compounds as potential antileishmanial inhibitors
Leishmaniasis is a severe disease caused by protozoan parasites of the genus Leishmania
and it is accountable for sizable morbidity and mortality worldwide. So far, no effective …
and it is accountable for sizable morbidity and mortality worldwide. So far, no effective …
The use of bis–thiadiazole and bis–oxadiazol derivatives as ionophores: a novel copper (II)–selective potentiometric electrodes
O Özbek, A Ölcenoglu - Microchemical Journal, 2023 - Elsevier
In this study, bis–thiadiazole and bis–oxadiazol derivative molecules were synthesized and
their ionophore properties were investigated. The synthesized bis–thiadiazole and bis …
their ionophore properties were investigated. The synthesized bis–thiadiazole and bis …
Structural features of 1, 3, 4-thiadiazole-derived ligands and their Zn (II) and Cu (II) complexes which demonstrate synergistic antibacterial effects with kanamycin
D Karcz, A Matwijczuk, D Kamiński, B Creaven… - International Journal of …, 2020 - mdpi.com
Classical synthetic protocols were applied for the isolation of three novel 1, 3, 4-thiadiazole
derivatives which were then complexed with the biologically important Cu (II) and Zn (II) …
derivatives which were then complexed with the biologically important Cu (II) and Zn (II) …
Design, synthesis, and molecular docking study of novel heterocycles incorporating 1, 3, 4-thiadiazole moiety as potential antimicrobial and anticancer agents
M El-Naggar, HA Sallam, SS Shaban… - Molecules, 2019 - mdpi.com
A new series of 5-(3, 5-dinitrophenyl)-1, 3, 4-thiadiazole derivatives were prepared and
evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds …
evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds …