Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in
various biological processes. However, little is known about the effects of lncRNAs on …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

The formation of adipocytes from precursor stem cells involves a complex and highly
orchestrated programme of gene expression. Our understanding of the basic network of …

The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …

Subsequently, with the evolution of longerliving organisms, p53 is thought to have acquired
the ability to respond to oncogenic signals, promoting apoptosis or senescence–a …

Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …