The potential role of FREM1 and its isoform TILRR in HIV-1 acquisition through mediating inflammation

MA Kashem, H Li, LR Liu, B Liang… - International Journal of …, 2021 - mdpi.com
FREM1 (Fras-related extracellular matrix 1) and its splice variant TILRR (Toll-like interleukin-
1 receptor regulator) have been identified as integral components of innate immune …

Natural Immunity against HIV-1: Progression of Understanding after Association Studies

M Luo - Viruses, 2022 - mdpi.com
Natural immunity against HIV has been observed in many individuals in the world. Among
them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained …

Simplified Cell Magnetic Isolation Assisted SC2 Chip to Realize “Sample in and Chemotaxis Out”: Validated by Healthy and T2DM Patients' Neutrophils

X Yang, C Gao, Y Liu, L Zhu, K Yang - Micromachines, 2022 - mdpi.com
Neutrophil migration in tissues critically regulates the human immune response and can
either play a protective role in host defense or cause health problems. Microfluidic chips are …

TILRR (Toll-like interleukin-1 receptor regulator), an important modulator of inflammatory responsive genes, is circulating in the blood

MA Kashem, XY Yuan, L Li, J Kimani… - Journal of …, 2021 - Taylor & Francis
Purpose TILRR (Toll-like interleukin-1 receptor regulator), a variant of FREM1 (Fras-related
extracellular matrix 1), is a modulator of many genes in NF-κB (nuclear factor kappa-light …

Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF

F Zhang, X Cui, K Yang, R Guo, L Zhu, W Zhao… - International …, 2024 - Elsevier
Activin A, a member of the transforming growth factor β (TGF-β) superfamily, is involved in
tumorigenesis and tumor progression. However, it remains unclear whether activin A can …

Toll-like Interleukin-1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

MA Kashem, L Li, XY Yuan, FA Plummer… - Journal of Inflammation …, 2022 - Taylor & Francis
Purpose TILRR is a modulator of genes in the NF-κB inflammation pathway. It regulates
inflammation-responsive genes, the secretion of inflammatory mediators, and the migration …

High level of plasma TILRR protein is associated with faster HIV seroconversion

MA Kashem, J Lischynski, B Stojak, L Li, XY Yuan… - …, 2022 - thelancet.com
Summary Background TILRR (Toll-like Interleukin-1 Receptor Regulator) is a modulator of
many genes in NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) …

Role of TILRR in modulating inflammatory responses relevant to vaginal HIV-1 acquisition

M Kashem - 2021 - mspace.lib.umanitoba.ca
Abstract TILRR (Toll-like Interleukin 1 Receptor Regulator) is a transcript variant of FREM1
(Fras-related extracellular matrix 1) and the expression of TILRR is observed in a broad …

High Plasma TILRR Protein Predicted High Risk of HIV Seroconversion

MA Kashem, J Lischynski, B Stojak, L Li… - Available at SSRN … - papers.ssrn.com
Background: TILRR (Toll-like Interleukin-1 Receptor Regulator) is a modulator of many
genes in NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling. It …