Antibiofilm activity of host defence peptides: complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

An overview of antimicrobial peptides and the latest advances in their development

JM Sierra, E Fusté, F Rabanal, T Vinuesa… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The recent dramatic increase in the incidence of antimicrobial resistance has
been recognized by organizations such as the United Nations and World Health …

Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides

T Sneideris, NA Erkamp, H Ausserwöger… - Nature …, 2023 - nature.com
Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial
cell membrane or interacting with intracellular targets, are naturally produced by a number of …

Biophysical investigations elucidating the mechanisms of action of antimicrobial peptides and their synergism

A Marquette, B Bechinger - Biomolecules, 2018 - mdpi.com
Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …

Computational antimicrobial peptide design and evaluation against multidrug-resistant clinical isolates of bacteria

D Nagarajan, T Nagarajan, N Roy, O Kulkarni… - Journal of Biological …, 2018 - ASBMB
There is a pressing need for new therapeutics to combat multidrug-and carbapenem-
resistant bacterial pathogens. This challenge prompted us to use a long short-term memory …

The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations

C Aisenbrey, A Marquette, B Bechinger - Antimicrobial Peptides: Basics …, 2019 - Springer
Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

[HTML][HTML] Antimicrobial activity of an artificially designed peptide against fish pathogens

RAH Bhat, VC Khangembam, D Thakuria, V Pant… - Microbiological …, 2022 - Elsevier
Antimicrobial peptides (AMPs) are considered alternatives to classical antibiotics and may
become an excellent candidate for tackling antimicrobial resistance in aquaculture …

Perspectives on the antibiotic contamination, resistance, metabolomics, and systemic remediation

KK Sodhi, M Kumar, B Balan, AS Dhaulaniya… - SN Applied …, 2021 - Springer
Antibiotics have been regarded as the emerging contaminants because of their massive use
in humans and veterinary medicines and their persistence in the environment. The global …

Structure and function in antimicrobial piscidins: histidine position, directionality of membrane insertion, and pH-dependent permeabilization

M Mihailescu, M Sorci, J Seckute, VI Silin… - Journal of the …, 2019 - ACS Publications
Piscidins are histidine-enriched antimicrobial peptides that interact with lipid bilayers as
amphipathic α-helices. Their activity at acidic and basic pH in vivo makes them promising …