Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Simple Summary Hypoxia is a common feature of solid tumors and associated with poor
outcome in most cancer types and treatment modalities, including radiotherapy …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …

Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Immunotherapy is poised to become an increasingly utilized therapy in the treatment of
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …

Homology-directed repair (HDR) safeguards DNA integrity under various forms of stress, but
how HDR protects replicating genomes under extensive metabolic alterations remains …

While it is widely accepted that high intratumoral heterogeneity confers serious challenges
in the emerging resistance and the subsequent effective therapeutic targeting of cancer, the …