Structural diversity of calmodulin binding to its target sites
H Tidow, P Nissen - The FEBS journal, 2013 - Wiley Online Library
Calmodulin (CaM) is a ubiquitous, highly conserved, eukaryotic protein that binds to and
regulates a number of diverse target proteins involved in different functions such as …
regulates a number of diverse target proteins involved in different functions such as …
Biology of cardiac sodium channel Nav1.5 expression
MB Rook, MM Evers, MA Vos… - Cardiovascular …, 2012 - academic.oup.com
Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …
is an integral membrane protein involved in the initiation and conduction of action potentials …
[HTML][HTML] Cardiac sodium channel NaV1. 5 distribution in myocytes via interacting proteins: the multiple pool model
The cardiac sodium current (INa) is responsible for the rapid depolarization of cardiac cells,
thus allowing for their contraction. It is also involved in regulating the duration of the cardiac …
thus allowing for their contraction. It is also involved in regulating the duration of the cardiac …
The Role of Late I Na in Development of Cardiac Arrhythmias
C Antzelevitch, V Nesterenko, JC Shryock… - Voltage gated sodium …, 2014 - Springer
Late I Na is an integral part of the sodium current, which persists long after the fast-
inactivating component. The magnitude of the late I Na is relatively small in all species and …
inactivating component. The magnitude of the late I Na is relatively small in all species and …
Crystallographic basis for calcium regulation of sodium channels
1649-Pos Board B419 Tailoring m-Conotoxin-KIIIA to Selectively Inhibit NaV1. 7 Jeff R.
McArthur, Gurpreet Singh, Denis McMaster, Robert Winkfein, D. Peter Tieleman, Robert J …
McArthur, Gurpreet Singh, Denis McMaster, Robert Winkfein, D. Peter Tieleman, Robert J …
Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels
Calmodulin regulation of CaV channels is a prominent Ca2+ feedback mechanism
orchestrating vital adjustments of Ca2+ entry. The long-held structural correlation of this …
orchestrating vital adjustments of Ca2+ entry. The long-held structural correlation of this …
Late sodium current inhibitors as potential antiarrhythmic agents
B Horváth, T Hézső, D Kiss, K Kistamás… - Frontiers in …, 2020 - frontiersin.org
Based on recent findings, an increased late sodium current (INa, late) plays an important
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …
Calmodulin in a heartbeat
AB Sorensen, MT Søndergaard… - The FEBS …, 2013 - Wiley Online Library
Calmodulin is the primary sensor of intracellular calcium (Ca2+) levels in eukaryotic cells
playing a key role in the proper deciphering of Ca2+ signalling. Given the versatility of Ca2+ …
playing a key role in the proper deciphering of Ca2+ signalling. Given the versatility of Ca2+ …
Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation
Ca2+ regulates voltage-gated Na+ (NaV) channels, and perturbed Ca2+ regulation of NaV
function is associated with epilepsy syndromes, autism and cardiac arrhythmias …
function is associated with epilepsy syndromes, autism and cardiac arrhythmias …
Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain
M Brohus, AO Busuioc, R Wimmer… - Frontiers in …, 2023 - frontiersin.org
Missense variants in CALM genes encoding the Ca2+-binding protein calmodulin (CaM)
cause severe cardiac arrhythmias. The disease mechanisms have been attributed to …
cause severe cardiac arrhythmias. The disease mechanisms have been attributed to …