The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

The term invasiveness describes the ability of cells to cross anatomic barriers, eg, basement
membranes, interstitial stroma, and intercellular junctions, that separate tissue …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

The low density lipoprotein receptor-related protein (LRP) Is a large multifunctional
clearance receptorthat has been implicated In the hepatlc uptake of chylomicron remnants …

The cellular receptor for human urokinase-type plasminogen activator (u-PAR) is shown by
several independent criteria to be a true member of a family of integral membrane proteins …

Urokinase receptors, expressed on surfaces of many cell types, focus to the pericellular
space plasminogen-dependent proteolysis important in matrix remodeling and cell …

The regulation of plasminogen activation involves genes for two plasminogen activators
(tissue type and urokinase type), two specific inhibitors (type 1 and type 2), and a membrane …

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process
in which the extracellular matrix (ECM) plays the dual role of the substratum on which the …

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-
anchored protein that binds with high-affinity and activates the serine protease uPA, thus …

Receptor-bound urokinase-type plasminogen activator (uPA) remains associated to the
surface of human monocytes for many hours. Monocytes induced to migrate in a chemotactic …