The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters
The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine)
and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative …
and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative …
Vasodysfunction that involves renal vasodysfunction, not abnormally increased renal retention of sodium, accounts for the initiation of salt-induced hypertension
RC Morris Jr, O Schmidlin, A Sebastian, M Tanaka… - Circulation, 2016 - Am Heart Assoc
According to prevailing theory, salt-sensitive subjects have an impaired renal ability to
excrete a salt load that usually causes them to retain more sodium than normal salt-resistant …
excrete a salt load that usually causes them to retain more sodium than normal salt-resistant …
[HTML][HTML] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
M Wakabayashi, T Mori, K Isobe, E Sohara, K Susa… - Cell reports, 2013 - cell.com
Mutations in WNK kinases cause the human hypertensive disease
pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK …
pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK …
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive
kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 …
kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 …
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron
E Vidal-Petiot, E Elvira-Matelot… - Proceedings of the …, 2013 - National Acad Sciences
Large deletions in the first intron of the With No lysine (K) 1 (WNK1) gene are responsible for
Familial Hyperkalemic Hypertension (FHHt), a rare form of human hypertension associated …
Familial Hyperkalemic Hypertension (FHHt), a rare form of human hypertension associated …
Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia
Deletion of exon 9 from Cullin‐3 (CUL 3, residues 403–459: CUL 3Δ403–459) causes
pseudohypoaldosteronism type IIE (PHA 2E), a severe form of familial hyperkalaemia and …
pseudohypoaldosteronism type IIE (PHA 2E), a severe form of familial hyperkalaemia and …
Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice
K Susa, E Sohara, T Rai, M Zeniya… - Human molecular …, 2014 - academic.oup.com
Pseudohypoaldosteronism type II (PHAII) is a hereditary disease characterized by salt-
sensitive hypertension, hyperkalemia and metabolic acidosis, and genes encoding with-no …
sensitive hypertension, hyperkalemia and metabolic acidosis, and genes encoding with-no …
Hydrostatic pressure sensing by WNK kinases
JM Humphreys, LR Teixeira, R Akella… - Molecular biology of …, 2023 - Am Soc Cell Biol
Previous study has demonstrated that the WNK kinases 1 and 3 are direct osmosensors
consistent with their established role in cell-volume control. WNK kinases may also be …
consistent with their established role in cell-volume control. WNK kinases may also be …
[HTML][HTML] IP3 receptors regulate vascular smooth muscle contractility and hypertension
Abstract Inositol 1, 4, 5-trisphosphate receptor–mediated (IP 3 R-mediated) calcium (Ca 2+)
release has been proposed to play an important role in regulating vascular smooth muscle …
release has been proposed to play an important role in regulating vascular smooth muscle …
[HTML][HTML] NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension
SN Orlov, SV Koltsova, LV Kapilevich, SV Gusakova… - Genes & diseases, 2015 - Elsevier
This review summarizes the data on the functional significance of ubiquitous (NKCC1) and
renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride …
renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride …