Abstract Context The European Association of Urology (EAU) Guidelines Panel on Upper
Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid …

The burden of disease and death attributable to environmental pollution is becoming a
public health challenge worldwide, especially in developing countries. The kidney is …

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and
prevent mutation. Here we use C. elegans whole genome sequencing to systematically …

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated
with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation …

Molecular mutagens and carcinogens are structures which carry chemical and electronic
properties that disturb and interact with the genomic machinery. Principally, a rule of thumb …

The term “aristolochic acid nephropathy”(AAN) is used to include any form of toxic interstitial
nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as …

Aristolochic acid (AA), a natural product of Aristolochia plants found in herbal remedies and
health supplements, is a group 1 carcinogen that can cause nephrotoxicity and upper …

Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus
Aristolochia and Asarum, which are spread all over the world. Since the 1990s, AA-induced …

Current non-invasive approaches for detection of urothelial cancers are suboptimal. We
developed a test to detect urothelial neoplasms using DNA recovered from cells shed into …