Photoclick chemistry: a bright idea
At its basic conceptualization, photoclick chemistry embodies a collection of click reactions
that are performed via the application of light. The emergence of this concept has had …
that are performed via the application of light. The emergence of this concept has had …
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that
are crucial for biomedical research and drug discovery. Various techniques have been used …
are crucial for biomedical research and drug discovery. Various techniques have been used …
Systems for stimuli-controlled release: Materials and applications
The design and development of delivery controlled systems of molecules of interest has
attracted great interest over the last years. pH variation, light irradiation, temperature …
attracted great interest over the last years. pH variation, light irradiation, temperature …
Self‐assembled nanomedicines for anticancer and antibacterial applications
L Zhou, T Qiu, F Lv, L Liu, J Ying… - Advanced Healthcare …, 2018 - Wiley Online Library
Self‐assembly strategies have been widely applied in the nanomedicine field, which provide
a convenient approach for building various structures for delivery carriers. When …
a convenient approach for building various structures for delivery carriers. When …
Photocrosslinking probes for capture of carbohydrate interactions
H Wu, J Kohler - Current opinion in chemical biology, 2019 - Elsevier
Glycan-mediated interactions are essential in many biological processes and regulate a
wide variety of cellular functions. However, characterizing these interactions is difficult …
wide variety of cellular functions. However, characterizing these interactions is difficult …
Design, synthesis, and utility of defined molecular scaffolds
A growing theme in chemistry is the joining of multiple organic molecular building blocks to
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …
Bio-related applications of porous organic frameworks (POFs)
H Zhang, G Li, C Liao, Y Cai, G Jiang - Journal of Materials Chemistry …, 2019 - pubs.rsc.org
Increasing attention has been given to the field of porous organic frameworks (POFs) due to
their unique properties, outstanding performance, and broad applications. Given their …
their unique properties, outstanding performance, and broad applications. Given their …
Photoswitchable CAR-T cell function in vitro and in vivo via a cleavable mediator
B Zhang, Y Wang, S Huang, J Sun, M Wang, W Ma… - Cell Chemical …, 2021 - cell.com
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer
treatment; however, they are hampered by constitutive activation, which leads to worrisome …
treatment; however, they are hampered by constitutive activation, which leads to worrisome …
Gold (I)-mediated decaging or cleavage of propargylated peptide bond in aqueous conditions for protein synthesis and manipulation
Chemists have been interested in the N-alkylation of a peptide bond because such a
modification alters the conformation of the amide bond, interferes with hydrogen bond …
modification alters the conformation of the amide bond, interferes with hydrogen bond …
Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome
Carnosic acid (CA), from rosemary, a food additive used for long history in western
countries, reduces triglyceride, cholesterol and glucose levels. However, the detailed …
countries, reduces triglyceride, cholesterol and glucose levels. However, the detailed …