The production of free radicals is inevitably associated with metabolism and other enzymatic
processes. Under physiological conditions, however, free radicals are effectively eliminated …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

Significant amounts of oxygen free radicals (oxidants) are generated during cerebral
ischemia/reperfusion, and oxidative stress plays an important role in brain damage after …

Reactive oxygen species have been implicated in brain injury after ischemic stroke. These
oxidants can react and damage the cellular macromolecules by virtue of the reactivity that …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

During apoptosis, mitochondrial membrane permeability (MMP) increases and the release
into the cytosol of pro-apoptotic factors (procaspases, caspase activators and caspase …

Significance: The intrinsic apoptosis pathway is conserved from worms to humans and plays
a critical role in the normal development and homeostatic control of adult tissues. As a result …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

Reactive oxygen species (ROS) are produced in many normal and abnormal processes in
humans, including atheroma, asthma, joint diseases, aging, and cancer. The superoxide …