Atopic disorders, including atopic dermatitis, food and environmental allergies, and asthma,
are increasingly prevalent diseases. Atopic disorders are often associated with eosinophilia …

Simple Summary Epstein–Barr Virus (EBV) is a common virus that is readily controlled by a
healthy immune system and rarely causes serious problems in infected people. However …

There is growing evidence to suggest that severe disease in children infected with common
viruses that are typically benign in other children can result from inborn errors of immunity or …

Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by β-human
papillomaviruses (HPV) in immunodeficient patients. EV is characterized by flat warts and …

The clinical penetrance of infectious diseases varies considerably among patients with
inborn errors of immunity (IEI), even for identical genetic defects. This variability is influenced …

Purpose Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive
genetic disorder leading to combined immunodeficiency; however, the extent to which …

Inborn errors of immunity cover a broad spectrum of diseases from immune deficiency
syndromes to hyperinflammatory conditions. Primary atopic disorders are a recent member …

Combined immunodeficiencies are potentially are the most serious of primary
immunodeficiencies and arise because of genetic defects affecting T-lymphocyte …

Leukemias and lymphomas are the dominant malignancies in childhood, comprising over
one third of all pediatric cancer cases. They are also prevalent in adulthood, each being …

Purpose. Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive
genetic disorder leading to combined immunodeficiency. The extent to which STK4 …