Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing
mobility and promoting obesity-associated health risks. We reviewed the literature to …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

抄録 Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic
syndrome (MetS). The purpose is to assess the suitability of a diet-induced obesity model for …

Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Background and Purpose Sodium butyrate (NaB), an epigenetic modifier, is effective in
promoting insulin sensitivity. The specific genomic loci and mechanisms underlying …

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …

Abstract Significance: Metabolic syndrome (MetS) is associated with a greater risk of
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …

The chronic low-level inflammation associated with obesity is known to deleteriously affect
muscle composition. However, the manner in which obesity leads to muscle loss has not …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …