Attentional set-shifting, as a measure of executive flexibility, has been a staple of
investigations into human cognition for over six decades. Mediated by the frontal cortex in …

Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …

Impaired hippocampal synaptic plasticity contributes to cognitive impairment in Huntington's
disease (HD). However, the molecular basis of such synaptic plasticity defects is not fully …

Altered brain iron content in the striatum of premanifest and manifest Huntington's disease
(HD) has been reported. However, its natural history remains unclear. This study aims to …

Monogenic mutations in the SHANK3 gene, which encodes a postsynaptic scaffold protein,
play a causative role in autism spectrum disorder (ASD). Although a number of mouse …

AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of
fast excitatory synaptic transmission throughout the brain. Changes in the properties and …

Age-associated neurodegenerative diseases, such as Alzheimer's disease, Parkinson's
disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a …

Research with non‐human primates (NHP) has been essential and effective in increasing
our ability to find cures for a large number of diseases that cause human suffering and …

Scientific excellence is a necessity for progress in biomedical research. As research
becomes ever more international, establishing international collaborations will be key to …

Although mouse models of Alzheimer's disease (AD) have provided tremendous
breakthroughs, the etiology of later onset AD remains unknown. In particular, tau pathology …