Previous interest in high-density lipoproteins (HDLs) focused on their possible protective
role in atherosclerotic cardiovascular disease (ASCVD). Evidence from genetic studies and …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

Cholesterol metabolism has been linked to immune functions, but the mechanisms by which
cholesterol biosynthetic signaling orchestrates inflammasome activation remain unclear …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with
increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) …

Dendritic cells (DCs) are innate immune cells that detect and process environmental signals
and communicate them with T cells to bridge innate and adaptive immunity. Immune signals …