Anti-hepatocellular carcinoma biomolecules: molecular targets insights

N Juaid, A Amin, A Abdalla, K Reese, Z Alamri… - International journal of …, 2021 - mdpi.com
This report explores the available curative molecules directed against hepatocellular
carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to …

Anti-obesity effects of capsaicin and the underlying mechanisms: A review

R Li, Y Lan, C Chen, Y Cao, Q Huang, CT Ho, M Lu - Food & function, 2020 - pubs.rsc.org
Obesity and overweight have become serious health problems in the world and are linked to
a variety of metabolic disorders. Phytochemicals with a weight-loss effect have been widely …

Capsaicin inhibits proliferation and induces apoptosis in breast cancer by down-regulating FBI-1-mediated NF-κB pathway

M Chen, C Xiao, W Jiang, W Yang, Q Qin… - Drug Design …, 2021 - Taylor & Francis
Background As a natural compound extracted from a variety of hot peppers, capsaicin has
drawn increasing attention to its anti-cancer effects against multiple human cancers …

The effects of capsaicin on gastrointestinal cancers

GDA Popescu, C Scheau, IA Badarau, MD Dumitrache… - Molecules, 2020 - mdpi.com
Gastrointestinal (GI) cancers are a group of diseases with very high positions in the ranking
of cancer incidence and mortality. While they show common features regarding the …

Capsaicin targets lipogenesis in HepG2 cells through AMPK activation, AKT inhibition and PPARs regulation

A Bort, BG Sánchez, PA Mateos-Gómez… - International journal of …, 2019 - mdpi.com
Obesity, a major risk factor for chronic diseases such as type 2 diabetes (T2D), represents a
serious primary health problem worldwide. Dietary habits are of special interest to prevent …

Melatonin suppresses NLRP3 inflammasome activation via TLR4/NF-κB and P2X7R signaling in high-fat diet-induced murine NASH model

M Saha, K Manna, K Das Saha - Journal of Inflammation Research, 2022 - Taylor & Francis
Background NLRP3 inflammasome activation plays a critical role in mediating inflammation
and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and …

TRPV1 activation by capsaicin mediates glucose oxidation and ATP production independent of insulin signalling in mouse skeletal muscle cells

P Vahidi Ferdowsi, KDK Ahuja, JM Beckett, S Myers - Cells, 2021 - mdpi.com
Background: Insulin resistance (IR), a key characteristic of type 2 diabetes (T2DM), is
manifested by decreased insulin-stimulated glucose transport in target tissues. Emerging …

Capsaicin: effects on the pathogenesis of hepatocellular carcinoma

C Scheau, IA Badarau, C Caruntu, GL Mihai… - Molecules, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most frequent cancers, and to date, there
have been very few drugs available that can improve survival, the most well-known being …

Modulating effects of capsaicin on glucose homeostasis and the underlying mechanism

W Liang, Y Lan, C Chen, M Song, J Xiao… - Critical Reviews in …, 2023 - Taylor & Francis
Abnormal glucose homeostasis is linked to a variety of metabolic syndromes, such as insulin
resistance, obesity, type-2 diabetes mellitus, hypertension and cardiovascular diseases …

Advances in understanding and harnessing the molecular regulatory mechanisms of vegetable quality

L Gao, N Hao, T Wu, J Cao - Frontiers in Plant Science, 2022 - frontiersin.org
The quality of vegetables is facing new demands in terms of diversity and nutritional health.
Given the improvements in living standards and the quality of consumed products …