Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

H Liu, Y Yu, A Dong, M Elsabahy, YW Yang… - Exploration, 2024 - Wiley Online Library
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …

Health benefits and pharmacological properties of hinokitiol

N El Hachlafi, F Lakhdar, A Khouchlaa, S Bakrim… - Processes, 2021 - mdpi.com
Hinokitiol is a natural bioactive compound found in several aromatic and medicinal plants. It
is a terpenoid synthetized and secreted by different species as secondary metabolites. This …

A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections

BX Hoang, B Han - Medical Hypotheses, 2020 - Elsevier
Zinc and the combination with zinc ionophore have been reported in basic research and
several clinical investigations as a potentially viable and economical preventive and …

[HTML][HTML] Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration

X Jin, M Zhang, J Lu, X Duan, J Chen, Y Liu… - Journal of Advanced …, 2021 - Elsevier
Introduction The increasing morbidity of fungal infections and the prevalence of drug
resistance highlighted the discovery of novel antifungal agents and investigation of their …

Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth

H Zhao, M Zhang, J Zhang, Z Sun, W Zhang, W Dong… - Cell & Bioscience, 2023 - Springer
Background Ferroptosis is a unique cell death, dependent on iron and phospholipid
peroxidation, involved in massive processes of physiopathology. Tremendous attention has …

Antimicrobial activity of biogenic metal oxide nanoparticles and their synergistic effect on clinical pathogens

DV Francis, MN Jayakumar, H Ahmad… - International Journal of …, 2023 - mdpi.com
The rising prevalence of antibiotic-resistance is currently a grave issue; hence, novel
antimicrobial agents are being explored and developed to address infections resulting from …

Current and potential applications of monoterpenes and their derivatives in oral health care

W Potocka, Z Assy, FJ Bikker, ML Laine - Molecules, 2023 - mdpi.com
Plant products have been employed in medicine for centuries. As the world becomes more
health-conscious, there is a growing interest in natural and minimally processed products for …

Evaluation of antibacterial activity expression of the hinokitiol/cyclodextrin complex against bacteria

Y Inoue, R Suzuki, I Murata, H Nomura, Y Isshiki… - Acs Omega, 2020 - ACS Publications
The purpose of this study was to assess the antimicrobial activity of a solid dispersion
prepared by mixing and grinding hinokitiol (HT) with α-cyclodextrin (αCD), β-cyclodextrin …

Design, synthesis and biological evaluation of 2-quinolyl-1, 3-tropolone derivatives as new anti-cancer agents

EA Gusakov, IA Topchu, AM Mazitova, IV Dorogan… - RSC …, 2021 - pubs.rsc.org
Tropolones are promising organic compounds that can have important biologic effects. We
developed a series of new 2-quinolyl-1, 3-tropolones derivatives that were prepared by the …

Zinc oxide nanoparticles functionalized with cinnamic acid for targeting dental pathogens receptor and modulating apoptotic genes in human oral epidermal …

OV Ravikumar, V Marunganathan, MSK Kumar… - Molecular Biology …, 2024 - Springer
Background Oral diseases are often attributed to dental pathogens such as S. aureus, S.
mutans, E. faecalis, and C. albicans. In this research work, a novel approach was employed …