Many studies have shown the central importance of the co-receptors CD28, inducible
costimulatory molecule (ICOS) and cytotoxic T lymphocyte antigen 4 (CTLA4) in the …

A successful immune response depends on the capacity of immune cells to travel from one
location in the body to another–these cells are rapid migrators, travelling at speeds of …

Silk fibroin (SF) and sericin (SS), the two major proteins of silk, are attractive biomaterials
with great potential in tissue engineering and regenerative medicine. However, their …

Cytotoxicity of human NK cells is activated by receptors that bind ligands on target cells, but
the relative contribution of the many different activating and inhibitory NK cell receptors is …

T cells use integrins in essentially all of their functions. They use integrins to migrate in and
out of lymph nodes and, following infection, to migrate into other tissues. At the beginning of …

Cells of the immune system communicate via the formation of receptor‐containing adhesive
junctions termed immunological synapses. Recently, retroviruses have been shown to …

Natural killer (NK) cells are important for early immune responses to viral infections and
cancer. Upon activation, NK cells secrete cytokines and chemokines, and kill sensitive target …

Abstract Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule
ligands, mediates T cell adhesion, but the signaling pathways and functional effects …

This study analyzes signaling events initiated through binding of the leukocyte integrin LFA-
1 to ICAM-1, which leads to T cell attachment, polarization and random migration. These …

Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by
crossing the endothelial monolayer that lines the vessels and migrate into the underlying …