The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …

Genome‐wide studies in tumor cells have indicated that chromatin‐modifying proteins are
commonly mutated in human cancers. The lysine‐specific methyltransferase 2C (KMT …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral
squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify …

Cervical cancer is the most common cancer affecting sub-Saharan African women and is
prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer …

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a
late-evolving epidermal appendage that has the primary function of providing nutrition for …

Self-renewing somatic tissues depend upon the proper balance of chromatin-modifying
enzymes to coordinate progenitor cell maintenance and differentiation, disruption of which …

Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the
epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin …