Anti-citrullinated protein antibody generation, pathogenesis, clinical application, and prospects

J Liu, J Gao, Z Wu, L Mi, N Li, Y Wang, X Peng… - Frontiers in …, 2022 - frontiersin.org
Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in
patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation …

Adaptive immunity in rheumatoid arthritis: anticitrulline and other antibodies in the pathogenesis of rheumatoid arthritis

L Klareskog, K Amara, V Malmström - Current opinion in …, 2014 - journals.lww.com
Several different triggering mechanisms are involved in forming an antibody repertoire that
evolves before the onset of clinical disease, and where antibodies with different specificities …

Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens

A Lerner, C Benzvi, A Vojdani - Scientific Reports, 2023 - nature.com
Microbial transglutaminase (mTG) is a bacterial survival factor, frequently used as a food
additive to glue processed nutrients. As a result, new immunogenic epitopes are generated …

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation

AJ Ytterberg, V Joshua, G Reynisdottir… - Annals of the …, 2015 - ard.bmj.com
Objectives Immunological events in the lungs might trigger production of anti-citrullinated
protein antibodies during early rheumatoid arthritis (RA). We investigated the presence of …

Affinity maturation of the anti–citrullinated protein antibody paratope drives epitope spreading and polyreactivity in rheumatoid arthritis

S Kongpachith, N Lingampalli, CH Ju… - Arthritis & …, 2019 - Wiley Online Library
Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis
(RA). While epitope spreading of the serum ACPA response is believed to contribute to RA …

Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial

A Kastbom, K Forslind, S Ernestam… - Annals of the …, 2016 - ard.bmj.com
Objective To determine the relationship between changes in antibody levels towards
citrullinated peptides derived from different candidate autoantigens and therapeutic outcome …

Anti-citrullinated protein antibodies and arthritis in Sjögren's syndrome: a systematic review and meta-analysis

N Molano-González, E Olivares-Martínez… - Scandinavian Journal …, 2019 - Taylor & Francis
Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren's
syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their …

Epitope specificity of anti-citrullinated protein antibodies

NH Trier, G Houen - Antibodies, 2017 - mdpi.com
Anti-citrullinated protein antibodies are primarily associated with a progressive course in the
autoimmune disease rheumatoid arthritis, a disease with a chronic and inflammatory nature …

Affinity purification and comparative biosensor analysis of citrulline-peptide-specific antibodies in rheumatoid arthritis

E Szarka, P Aradi, K Huber, J Pozsgay, L Végh… - International Journal of …, 2018 - mdpi.com
Background: In rheumatoid arthritis (RA), anti-citrullinated protein/peptide antibodies
(ACPAs) are responsible for disease onset and progression, however, our knowledge is …

[HTML][HTML] Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients

J Li, Y Liang, H Mao, W Deng… - Pakistan Journal of Medical …, 2014 - ncbi.nlm.nih.gov
Objective: To study the effects of B-lymphocyte dysfunction on the serum copper, selenium
and zinc levels of rheumatoid arthritis (RA) patients, and to provide evidence for clinical …