Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of
an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT …

Abstract Purpose of Review Immune checkpoint inhibitors (ICIs) have improved the survival
of several cancers. However, they may cause a wide range of immune-related adverse …

The successful treatment of human cancers by immunotherapy has been made possible by
breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD …

The immune system plays an essential and central role in tumor cell differentiation,
proliferation, angiogenesis, apoptosis, invasion, and metastasis. Over the past decade …

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute
a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma …

Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR)
stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding …

Depression is a common comorbidity in cancer cases, but this is not only due to the
emotional distress of having a life-threatening disease. A common biological mechanism …

Metformin is one of the most commonly used first-line oral medications for type 2 diabetes
mellitus. Multiple observational studies, reviewed in numerous systematic reviews, have …

Purpose Disitamab vedotin (RC48) is an HER2-directed antibody–drug conjugate, emerging
as an effective strategy for cancer therapy, which not only enhances antitumor immunity in …

Abstract Purpose of Review The treatment options for high-risk non-muscle invasive bladder
cancer (NMIBC), particularly following BCG, remain limited. We highlight recent, promising …