[HTML][HTML] Spheroid culture system methods and applications for mesenchymal stem cells
Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …
have extensively studied them to optimize the culture conditions and increase efficiency of …
RANKL/RANK/OPG pathway: A mechanism involved in exercise‐induced bone remodeling
Bones as an alive organ consist of about 70% mineral and 30% organic component. About
200 million people are suffering from osteopenia and osteoporosis around the world. There …
200 million people are suffering from osteopenia and osteoporosis around the world. There …
[HTML][HTML] Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment
L Hu, C Yin, F Zhao, A Ali, J Ma, A Qian - International Journal of …, 2018 - mdpi.com
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …
degraded bone microstructure, which leads to increased bone fragility and risks of bone …
[HTML][HTML] Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
During bone resorption, abundant factors previously buried in the bone matrix are released
into the bone marrow microenvironment, which results in recruitment and differentiation of …
into the bone marrow microenvironment, which results in recruitment and differentiation of …
Disorders of bone remodeling
X Feng, JM McDonald - Annual Review of Pathology …, 2011 - annualreviews.org
The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …
Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications
Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue
engineering and are being tested in clinical trials for a wide range of diseases. Originally …
engineering and are being tested in clinical trials for a wide range of diseases. Originally …
[HTML][HTML] Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications
D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
Mechanical regulation of signaling pathways in bone
A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …
physiological responses. The skeleton is particularly dependent on mechanical information …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Nature genetics, 2009 - nature.com
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …