Owing to the importance of stem cell culture systems in clinical applications, researchers
have extensively studied them to optimize the culture conditions and increase efficiency of …

Bones as an alive organ consist of about 70% mineral and 30% organic component. About
200 million people are suffering from osteopenia and osteoporosis around the world. There …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

During bone resorption, abundant factors previously buried in the bone matrix are released
into the bone marrow microenvironment, which results in recruitment and differentiation of …

The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue
engineering and are being tested in clinical trials for a wide range of diseases. Originally …

Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …