Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal
transducers. They regulate essential cellular processes like proliferation, apoptosis …

VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling
pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of
glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab …

Development of hypoxic regions is an indicator of poor prognosis in many tumors. Here, we
demonstrate that HIF1α, the direct effector of hypoxia, partly through increases in SDF1α …

Src family kinases (SFKs) have a critical role in cell adhesion, invasion, proliferation,
survival, and angiogenesis during tumor development. SFKs comprise nine family members …

Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell
autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of …

The establishment of a vascular supply is one of the earliest and most important events
occurring during embryonic development. Growth and maturation of a functional vascular …