Toward an understanding of the structural and mechanistic aspects of protein-protein interactions in 2-oxoacid dehydrogenase complexes
The 2-oxoglutarate dehydrogenase complex (OGDHc) is a key enzyme in the tricarboxylic
acid (TCA) cycle and represents one of the major regulators of mitochondrial metabolism …
acid (TCA) cycle and represents one of the major regulators of mitochondrial metabolism …
[HTML][HTML] A Novel Her2/VEGFR2/CD3 trispecific antibody with an optimal structural design showed improved T-cell-redirecting antitumor efficacy
D Liu, X Qi, X Wei, L Zhao, X Wang, S Li, Z Wang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: T-cell-redirecting bispecific antibodies (bsAbs) and trispecific antibodies (tsAbs)
designed to recognize different epitopes or antigens have emerged as promising cancer …
designed to recognize different epitopes or antigens have emerged as promising cancer …
MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex
JF Hevler, P Albanese, A Cabrera-Orefice… - Open …, 2023 - royalsocietypublishing.org
The tricarboxylic acid cycle is the central pathway of energy production in eukaryotic cells
and plays a key part in aerobic respiration throughout all kingdoms of life. One of the pivotal …
and plays a key part in aerobic respiration throughout all kingdoms of life. One of the pivotal …
Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex
CA Brautigam, RM Wynn, JL Chuang… - Journal of Biological …, 2009 - ASBMB
The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine
that employs three catalytic components, ie pyruvate dehydrogenase (E1p), dihydrolipoyl …
that employs three catalytic components, ie pyruvate dehydrogenase (E1p), dihydrolipoyl …
Live cell discovery of microbial vitamin transport and enzyme-cofactor interactions
The rapid completion of microbial genomes is inducing a conundrum in functional gene
discovery. Novel methods are needed to shorten the gap between characterizing a microbial …
discovery. Novel methods are needed to shorten the gap between characterizing a microbial …
Nuclear magnetic resonance approaches in the study of 2-oxo acid dehydrogenase multienzyme complexes—a literature review
The 2-oxoacid dehydrogenase complexes (ODHc) consist of multiple copies of three
enzyme components: E1, a 2-oxoacid decarboxylase; E2, dihydrolipoyl acyl-transferase; …
enzyme components: E1, a 2-oxoacid decarboxylase; E2, dihydrolipoyl acyl-transferase; …
Functional versatility of the human 2-oxoadipate dehydrogenase in the L-lysine degradation pathway toward its non-cognate substrate 2-oxopimelic acid
The human 2-oxoadipate dehydrogenase complex (OADHc) in L-lysine catabolism is
involved in the oxidative decarboxylation of 2-oxoadipate (OA) to glutaryl-CoA and NADH (+ …
involved in the oxidative decarboxylation of 2-oxoadipate (OA) to glutaryl-CoA and NADH (+ …
Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step
A Balakrishnan, NS Nemeria… - Journal of the …, 2012 - ACS Publications
Spectroscopic identification and characterization of covalent and noncovalent intermediates
on large enzyme complexes is an exciting and challenging area of modern enzymology. The …
on large enzyme complexes is an exciting and challenging area of modern enzymology. The …
Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2· E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D …
The human pyruvate dehydrogenase complex (PDC) comprises three principal catalytic
components for its mission: E1, E2, and E3. The core of the complex is a strong subcomplex …
components for its mission: E1, E2, and E3. The core of the complex is a strong subcomplex …
Mutagenesis of conserved active site residues of dihydrolipoamide succinyltransferase enhances the accumulation of α-ketoglutarate in Yarrowia lipolytica
Abstract α-Ketoglutarate (α-KG) is an important intermediate in the tricarboxylic acid cycle
and has broad applications. The mitochondrial ketoglutarate dehydrogenase (KGDH) …
and has broad applications. The mitochondrial ketoglutarate dehydrogenase (KGDH) …