Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a
major contributor to death or disability worldwide and has become a heavy societal and …

Stroke is an acute cerebrovascular disease caused by sudden rupture of blood vessels in
the brain or blockage of blood vessels, which has now become one of the main causes of …

Hypoxia acts as an important regulator of physiological and pathological processes.
Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to …

Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide
(NO•), a molecule that is involved in the regulation of proper blood flow, vasodilation …

In human cells oxygen levels are 'sensed'by a set of ferrous iron and 2-oxoglutarate
dependent dioxygenases. These enzymes regulate a broad range of cellular and systemic …

Hypoxia-inducible factors mediate adaptive responses to ischemia, among others, by
induction of anti-and pro-survival genes. Thus, the impact of HIF on neuronal survival upon …

Ischemic stroke is a leading cause of disability and mortality worldwide due to the narrow
therapeutic window of the only approved therapies like intravenous thrombolysis and …

Human health is dependent on the ability of the body to extract nutrients, fluids, and oxygen
from the external environment while at the same time maintaining a state of internal sterility …