The promise and challenge of high-throughput sequencing of the antibody repertoire
G Georgiou, GC Ippolito, J Beausang, CE Busse… - Nature …, 2014 - nature.com
Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …
organs using high-throughput DNA sequencing technologies have been advancing at an …
Identification and specificity of broadly neutralizing antibodies against HIV
LE McCoy, DR Burton - Immunological reviews, 2017 - Wiley Online Library
Beginning in 2009, studies of the humoral responses of HIV‐positive individuals have led to
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
the identification of scores, if not hundreds, of antibodies that are both broadly reactive and …
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
D Sok, MJ van Gils, M Pauthner… - Proceedings of the …, 2014 - National Acad Sciences
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are
favored candidates for vaccine design and immunotherapy because of their great …
favored candidates for vaccine design and immunotherapy because of their great …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
Over the past 5 years, a new generation of highly potent and broadly neutralizing HIV-1
antibodies has been identified. These antibodies can protect against lentiviral infection in …
antibodies has been identified. These antibodies can protect against lentiviral infection in …
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
Bioinformatic and statistical analysis of adaptive immune repertoires
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …
analysis of adaptive immune responses and offers the potential to revolutionize research in …
Engineering HIV-resistant, anti-HIV chimeric antigen receptor T cells
M Hale, T Mesojednik, GSR Ibarra, J Sahni, A Bernard… - Molecular therapy, 2017 - cell.com
The treatment or cure of HIV infection by cell and gene therapy has been a goal for decades.
Recent advances in both gene editing and chimeric antigen receptor (CAR) technology …
Recent advances in both gene editing and chimeric antigen receptor (CAR) technology …
Antibody therapies for the prevention and treatment of viral infections
Antibodies are an important component in host immune responses to viral pathogens.
Because of their unique maturation process, antibodies can evolve to be highly specific to …
Because of their unique maturation process, antibodies can evolve to be highly specific to …