[HTML][HTML] Vascular calcification—new insights into its mechanism
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …
depending on the site (s) involved within the vessel, is closely related to cardiovascular …
Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation
SR Khan, BK Canales… - Nature Reviews …, 2021 - nature.com
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …
present on kidney papillary surfaces. Similar to the plaques formed during vascular …
The Klotho proteins in health and disease
M Kuro-o - Nature Reviews Nephrology, 2019 - nature.com
Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …
Vascular smooth muscle cell calcification is mediated by regulated exosome secretion
AN Kapustin, MLL Chatrou, I Drozdov, Y Zheng… - Circulation …, 2015 - Am Heart Assoc
Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form
the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is …
the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is …
The role of AGE/RAGE signaling in diabetes‐mediated vascular calcification
AM Kay, CLS Simpson… - Journal of diabetes …, 2016 - Wiley Online Library
AGE/RAGE signaling has been a well‐studied cascade in many different disease states,
particularly diabetes. Due to the complex nature of the receptor and multiple intersecting …
particularly diabetes. Due to the complex nature of the receptor and multiple intersecting …
[HTML][HTML] Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression
The Western pattern diet is rich not only in fat and calories but also in phosphate. The
negative effects of excessive fat and calorie intake on health are widely known, but the …
negative effects of excessive fat and calorie intake on health are widely known, but the …
Arterial stiffness: a focus on vascular calcification and its link to bone mineralization
This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …
highlighting the important genetic factors, systemic and local microenvironmental signals …
[HTML][HTML] The structure, biosynthesis, and biological roles of fetuin-A: A review
E Chekol Abebe, Z Tilahun Muche… - Frontiers in cell and …, 2022 - frontiersin.org
Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …
[HTML][HTML] Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
Abstract Increased extracellular Ca2+ concentrations ([Ca2+] ex) trigger activation of the
NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent …
NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent …
A current understanding of vascular calcification in CKD
NJ Paloian, CM Giachelli - American Journal of Physiology …, 2014 - journals.physiology.org
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have
significant cardiovascular morbidity and mortality that is in part due to the development of …
significant cardiovascular morbidity and mortality that is in part due to the development of …