Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
[HTML][HTML] Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
T Xu, L Zhang - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
Pre‐exascale HPC approaches for molecular dynamics simulations. Covid‐19 research: A use case
Exascale computing has been a dream for ages and is close to becoming a reality that will
impact how molecular simulations are being performed, as well as the quantity and quality of …
impact how molecular simulations are being performed, as well as the quantity and quality of …
Natural products as potential therapeutic agents for SARS-CoV-2: a medicinal chemistry perspective
V Aggarwal, E Bala, P Kumar, P Raizada… - Current Topics in …, 2023 - ingentaconnect.com
Coronavirus is a single-stranded RNA virus discovered by virologist David Tyrrell in 1960.
Till now seven human corona viruses have been identified including HCoV-229E …
Till now seven human corona viruses have been identified including HCoV-229E …
The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic
BA Comunale, RJ Larson, E Jackson-Ward, A Singh… - Viruses, 2023 - mdpi.com
Background: As long as COVID-19 endures, viral surface proteins will keep changing and
new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective …
new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective …
Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication …
Viral infection relies on the hijacking of cellular machineries to enforce the reproduction of
the infecting virus and its subsequent diffusion. In this context, the replication of the viral …
the infecting virus and its subsequent diffusion. In this context, the replication of the viral …
SARS-CoV-2 RNA-Dependent RNA Polymerase Follows Asynchronous Translocation Pathway for Viral Transcription and Replication
X Wang, T Xu, Y Yao, PPH Cheung… - The Journal of …, 2023 - ACS Publications
Translocation is one essential step for the SARS-CoV-2 RNA-dependent RNA polymerase
(RdRp) to exert viral replication and transcription. Although cryo-EM structures of SARS-CoV …
(RdRp) to exert viral replication and transcription. Although cryo-EM structures of SARS-CoV …
Viral RNA replication suppression of SARS-CoV-2: Atomistic insights into inhibition mechanisms of RdRp machinery by ddhCTP
The nonstructural protein 12, known as RNA-dependent RNA polymerase (RdRp), is
essential for both replication and repair of the viral genome. The RdRp of SARS-CoV-2 has …
essential for both replication and repair of the viral genome. The RdRp of SARS-CoV-2 has …
In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS‐CoV‐2 RNA‐Dependent RNA Polymerase
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus that causes
COVID‐19, has been a global concern. While there have been some vaccines and drugs …
COVID‐19, has been a global concern. While there have been some vaccines and drugs …
On the recognition of natural substrate CTP and endogenous inhibitor ddhCTP of SARS-CoV-2 RNA-dependent RNA polymerase: A molecular dynamics study
The novel coronavirus SARS-CoV-2 is the causative agent of the COVID-19 outbreak that is
affecting the entire planet. As the pandemic is still spreading worldwide, with multiple …
affecting the entire planet. As the pandemic is still spreading worldwide, with multiple …