The 2016 revision of the World Health Organization classification of tumors of hematopoietic
and lymphoid tissues is characterized by a closer integration of morphology and molecular …

The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

Refractory anemia with ring sideroblasts (RARS) is a myelodysplastic syndrome (MDS)
characterized by isolated erythroid dysplasia and 15% or more bone marrow ring …

Iron overload is a pathological condition resulting from a congenital impairment of its
regulation, increased intestinal iron absorption secondary to bone marrow erythroid …

The definition 'iron loading anaemias' encompasses a group of inherited and acquired
anaemias characterized by ineffective erythropoiesis, low hepcidin levels, excessive iron …

Myelodysplastic syndromes (MDSs) are a group of heterogeneous clonal bone marrow
disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias, and …

SF3B1 is the most frequently mutated RNA splicing factor in cancer, including in∼ 25% of
myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly …

Myelodysplastic syndromes (MDS) with ring sideroblasts are hematopoietic stem cell
disorders with erythroid dysplasia and mutations in the SF3B1 splicing factor gene. Patients …

Excess iron can be extremely toxic for the body and may cause organ damage in the
absence of iron chelation therapy. Preclinical studies on the role of free iron on bone marrow …

Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone
hepcidin are pivotal to discriminate between the bioactive 25-amino acid form that can …