Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …

One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …

Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Although targeted therapies often elicit profound initial patient responses, these effects are
transient due to residual disease leading to acquired resistance. How tumors transition …

Thyroid cancer incidence is increasing at an alarming rate, almost tripling every decade. In
2017, it was the fifth most common cancer in women. Although the majority of thyroid tumors …

Purpose: Morphologically heterogeneous prostate cancers that behave clinically like small-
cell prostate cancers (SCPC) share their chemotherapy responsiveness. We asked whether …

Background Alisertib is an investigational, oral, selective inhibitor of aurora kinase A. We
aimed to investigate the safety and activity of single-agent alisertib in patients with …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …