Pancreatic neuroendocrine neoplasms (panNENs) are heterogeneous neoplasms with
neuroendocrine differentiation that show characteristic clinical, histomorphologic, and …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

Abstract Five member heterocyclic 1, 3, 4-oxadiazole nucleus find unique place in medicinal
chemistry and plays significant role in producing anticancer activity. The small and simple 1 …

In mammals, DNA methylation is essential for protecting repetitive sequences from aberrant
transcription and recombination. In some developmental contexts (eg, preimplantation …

Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

Background Obesity, mainly visceral obesity, and metabolic syndrome (MetS) are major risk
factors for the development of type 2 diabetes, cardiovascular diseases, and cancer. Data …

Small cell lung cancer (SCLC) is a severe malignant with high morbidity; however, few
effective and secure therapeutic strategy is used in current clinical practice. Oridonin is a …

Inactivating MEN1 mutations are the most common genetic defects present in sporadic and
inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies …

Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …