Cancer drug delivery in the nano era: An overview and perspectives

Z Li, S Tan, S Li, Q Shen, K Wang - Oncology reports, 2017 - spandidos-publications.com
Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials
also appeal to researchers in the areas of cancer diagnosis and biomarker discovery …

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the
in vivo effectiveness of drugs is now well established. The development of multifunctional …

PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery

D Luong, P Kesharwani, R Deshmukh, MCIM Amin… - Acta biomaterialia, 2016 - Elsevier
Abstract Poly (amidoamine) dendrimers (PAMAM) are well-defined, highly branched,
nanoscale macromolecules with numerous active amine groups on the surface. PAMAM …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Cationic polymers and their therapeutic potential

SK Samal, M Dash, S Van Vlierberghe… - Chemical Society …, 2012 - pubs.rsc.org
The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

Y Cheng, L Zhao, Y Li, T Xu - Chemical Society Reviews, 2011 - pubs.rsc.org
In the past decade, nanomedicine with its promise of improved therapy and diagnostics has
revolutionized conventional health care and medical technology. Dendrimers and dendrimer …

Dendrimer‐based nanocarriers: a versatile platform for drug delivery

HJ Hsu, J Bugno, S Lee, S Hong - … Reviews: Nanomedicine and …, 2017 - Wiley Online Library
Advances in nanotechnology have had profound impacts on therapeutic delivery, leading to
the development of nanomaterials engineered with large carrying capabilities and targeting …

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

W She, K Luo, C Zhang, G Wang, Y Geng, L Li, B He… - Biomaterials, 2013 - Elsevier
Nanoparticles, such as dendritic polymers, are currently investigated as excellent
candidates for drug delivery vehicles. In this study, we report the preparation and …

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

SS Abolmaali, AM Tamaddon, R Dinarvand - Cancer chemotherapy and …, 2013 - Springer
Purpose Methotrexate (MTX) is one of the most widely studied and effective therapeutics
agents available to treat many solid tumors, hematologic malignancies, and autoimmune …

Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation

JA Mills, F Liu, TR Jarrett, NL Fletcher… - Biomaterials …, 2022 - pubs.rsc.org
For decades, nanomedicines have been reported as a potential means to overcome the
limitations of conventional drug delivery systems by reducing side effects, toxicity and the …