Cytokines play critical roles in regulating the development, survival, differentiation, and
function of immune cells. Cytokines exert their function by binding specific receptor …

The suppressor of cytokine signalling‐3 (SOCS 3) is well known as a feedback inhibitor of
the Janus kinases‐signal transducer and activator of transcription 3 (JAK/STAT 3) signalling …

CD4+ follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the
generation of high-affinity humoral responses. They express the chemokine receptor …

T follicular helper cell (TFH)–dependent antibody responses are critical for long-term
immunity. Antibody responses are diminished in early life, limiting long-term protective …

The signal transducer and activator of transcription (STAT) proteins are important mediators
for the integration of extrinsic signals provided by cytokines and hormones and thereby …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it …

Identifying immune correlates of protection and mechanisms of immunity accelerates and
streamlines the development of vaccines. RTS, S/AS01E, the most clinically advanced …

Over the course of the last three decades, a large body of evidence has shown that
polyphenols, the secondary metabolites occurring in plant foods and beverages, exert …

The metabolic principles underlying the differences between follicular and marginal zone B
cells (FoB and MZB, respectively) are not well understood. Here we show, by studying mice …

The IL-6 cytokine family signals through the common signal transduction molecule gp130
combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in …