SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

Infectious diarrhea: Cellular and molecular mechanisms

K Hodges, R Gill - Gut microbes, 2010 - Taylor & Francis
Diarrhea caused by enteric infections is a major factor in morbidity and mortality worldwide.
An estimated 2-4 billion episodes of infectious diarrhea occur each year and are especially …

SLC9/NHE gene family, a plasma membrane and organellar family of Na+/H+ exchangers

M Donowitz, CM Tse, D Fuster - Molecular aspects of medicine, 2013 - Elsevier
This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

Secretory diarrhoea: mechanisms and emerging therapies

JR Thiagarajah, M Donowitz… - … reviews Gastroenterology & …, 2015 - nature.com
Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

Role of colonic short-chain fatty acid transport in diarrhea

HJ Binder - Annual review of physiology, 2010 - annualreviews.org
Short-chain fatty acids (SCFA) are the major anion in stool and are synthesized from
nonabsorbed carbohydrate by the colonic microbiota. Nonabsorbed carbohydrate are not …

Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea

VK Viswanathan, K Hodges, G Hecht - Nature Reviews Microbiology, 2009 - nature.com
Infectious diarrhoea is a significant contributor to morbidity and mortality worldwide. In
bacterium-induced diarrhoea, rapid loss of fluids and electrolytes results from inhibition of …

Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells

L de Souza Goncalves, T Chu, R Master… - The Journal of …, 2024 - Am Soc Clin Investig
Cholera is a global health problem with no targeted therapies. The Ca2+-sensing receptor
(CaSR) is a regulator of intestinal ion transport and a therapeutic target for diarrhea, and …

[HTML][HTML] The Role of Ion Transporters in the Pathophysiology of InfectiousáDiarrhea

S Das, R Jayaratne, KE Barrett - Cellular and molecular gastroenterology …, 2018 - Elsevier
Every year, enteric infections and associated diarrhea kill millions of people. The situation is
compounded by increases in the number of enteric pathogens that are acquiring resistance …

Effects of Clostridium butyricum, Sodium Butyrate, and Butyric Acid Glycerides on the Reproductive Performance, Egg Quality, Intestinal Health, and Offspring …

Y Wang, Y Wang, X Lin, Z Gou, Q Fan… - Frontiers in …, 2021 - frontiersin.org
Butyrate has been reported to promote the performance and growth of chickens. The specific
roles and efficacy of different sources of butyrate remained unclear. Thus, the present study …

New functions and roles of the Na+-H+-exchanger NHE3

JA Dominguez Rieg, T Rieg - Pflügers Archiv-European Journal of …, 2024 - Springer
The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney,
where it contributes to hydrogen secretion and sodium (re) absorption. The roles of this …